Dental phenotype in Crouzon syndrome: A controlled radiographic study in 22 patients

This retrospective radiographic controlled study investigates the dental phenotype in patients with Crouzon syndrome to determine if differences are observed as suggested by FGFR2C342Y/+ mouse models, and whether these models could be of interest role this mutation tooth development. We assessed using dedicated linear measurements 22 children compared morphology both primary permanent dentitions an age-matched control group. Descriptive statistics were performed “Sex” “Age” covariates for only take into account potential confounding factors. showed that but not dimensions globally reduced syndrome, without microdontia. In dentition, crown height, mesiodistal faciolingual cervical diameters 6.3%, 5.7% 5.5% respectively (p < 0.05). Our results underline implication Fibroblast Growth Factor Receptor 2 (FGFR2) development humans contribute support partial replicas condition, including oral region.